Application Notes

From Automated Plasmid Purification to In Vitro Transcription and mRNA Purification: Use Case for Early Discovery of mRNA-based Therapeutics

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Kiranmai Durvasula¹, Carisa Townsend¹, Julie Baggs¹, and Travis Butts¹ ¹Omega Bio-tek, Inc, Norcross, GA 30071 Introduction Plasmids play a crucial role in the manufacturing and development of mRNA-based vaccines and therapeutics. As essential tools in molecular biology, plasmids serve as templates for in vitro transcription (IVT) processes, enabling the production of high-quality mRNA molecules for […]

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Evaluation and Comparison of Yield, Quality, and Next Generation Sequencing Metrics of DNA and RNA Extracted from the Same FFPE Sample Using Three Commercially Available Kits

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Danny Flanigan¹, Lauren Golan¹, Archie Li¹, Kiranmai Durvasula¹, Chris Stuart¹, Julie Baggs¹, and Travis Butts¹ ¹Omega Bio-tek, Inc, Norcross, GA 30071 Introduction Formalin-fixed paraffin-embedded (FFPE) tissue samples are invaluable biospecimens that are increasingly being used in molecular level analyses and gene expression studies aiding the fields of cancer genomics, pathological diagnosis, biomarker discovery, immunotherapy research,

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Automated Plasmid Midi Preps on a MagBinder® Fit24

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The Mag-Bind® Endo-free Plasmid Midi Kit (M1272) extracts high-yielding, high-quality plasmid DNA from a wide range of plasmid types and culture media:

  • High-yielding – Plasmid DNA yield up to 200 μg
  • Versatile – Process up to 50 mL bacterial culture with different plasmid types and culture medias
  • Transfection-quality – Endotoxin free plasmid DNA with endotoxins levels < 0.1 EU/µg
  • Pure – Contamination-free plasmid DNA with A260/A280 > 1.8 and A260/A230 > 1.8

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