Cell-free DNA (cfDNA) refers to small DNA fragments found in the bloodstream and other bodily fluids, such as spinal fluid and urine. These fragments are derived from various sources, including the breakdown of cells, the release of DNA from damaged or dying cells, and the shedding of DNA by normal cells. The presence of cfDNA […]
What is cell-free DNA (cfDNA)? Read More »
Formalin-fixed paraffin-embedded (FFPE) tissue samples are commonly used for preserving and storing biological samples, such as cancer tumor samples, for future analysis. However, the formalin fixation and paraffin embedding process can significantly impact the quality and yield of extracted DNA, making it challenging for downstream applications such as PCR and NGS. Omega Bio-tek developed the Mag-Bind® FFPE
Research publication review and discussion: “Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring”, Nature Medicine. Circulating, cell-free DNA (cfDNA) holds great clinical significance for non-invasive disease detection, diagnosis, and monitoring for tumor, cancer, or fetal DNA studies. Circulating DNA extraction is often challenging as they are found in low quantities, and accurate, consistent methods
