Product Application

Automated Plasmid Purifications using the MagBinder® Fit24: Mini, Midi, and More

Application Notes, Automated Solutions, Product Application / By

Steven Cupello¹, Chris Stuart¹, Kiranmai Durvasula¹, Julie Baggs¹, and Travis Butts¹ ¹Omega Bio-tek, Inc., Norcross, GA 30071 MagBinder® Fit24 Nucleic Acid Purification System Figure 1. MagBinder® Fit24 Nucleic Acid Purification System The MagBinder® Fit24 is a new benchtop nucleic acid purification system designed to meet the needs of low-to-moderate throughput users by providing semi-automated purification […]

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Using ddPCR to Detect Rare Variant Alleles in cfDNA Samples on the MagBinder® Fit24 Platform

Application Notes, Clean Up, Downstream Applications, Oncology, Precision Medicine, Product Application / By

Carisa Townsend1, Kiranmai Durvasula1, Julie Baggs1, and Travis Butts1 Omega Bio-tek, Inc, Norcross, GA 30071 Introduction Recent advancements and studies have demonstrated the potential of cfDNA as a universal, non-invasive biomarker in cancer prognosis, diagnosis, and prenatal testing. cfDNA are found in low abundance and in a background of contaminating genomic DNA making it a

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RNA Depletion in Plasmid DNA Extractions with Mag-Bind® TotalPure NGS

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Introduction Traditionally, plasmid DNA purification hinges on alkaline lysis. In this method, bacteria, typically E. coli, containing the targeted plasmid DNA are harvested from overnight culture and resuspended in solution. A highly alkaline solution containing a detergent lyses the bacteria cells and denatures both the plasmid and genomic DNA. The addition of a highly acidic

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DNA from Saliva Performs Well Downstream, Despite Poor A260/A230 Ratios

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The non-invasive nature of sample collection makes saliva an appealing sample type for patients and researchers alike. However, one hindrance to using saliva for genomic analysis is the appearance of low purity in eluates when quantified using absorbance ratios. Here, we discuss the nature of absorbance ratios and contextualize their meaning when analyzing extractions from

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DNA Sequencing Could Help Restore Genomic Diversity to at-risk Populations of Pumas in California

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Introduction The consequences of the expansion of human development have been especially felt in California where human activity has eradicated several apex predators, like the California Grizzly and gray wolf. Unlike these predators, the puma, also called the mountain lion or cougar, has continued to populate the state, though their population is threatened by the continued

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What is PCR?

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Polymerase Chain Reaction (PCR) is a molecular biology technique used to amplify and replicate specific segments of DNA. Over time, PCR technology has evolved, giving rise to various methodologies, each tailored to specific needs. In this blog post, we will explore the different types of PCR and their applications.  Standard PCR Conventional PCR enables the

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What is NGS?

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Next-Generation Sequencing (NGS) is a cutting-edge technology used to sequence nucleotides in a DNA or RNA molecule. Unlike Sanger Sequencing, which can sequence only one DNA fragment at a time, NGS allows researchers to sequence multiple DNA fragments in parallel in a single run. This high-throughput approach revolutionizes our ability to decode complex genomes efficiently

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News

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The non-invasive nature of sample collection makes saliva an appealing sample type for patients and researchers alike. However, one hindrance to using saliva for genomic analysis is the appearance of low purity in eluates when quantified using absorbance ratios. Here, we discuss the nature of absorbance ratios and contextualize their meaning when analyzing extractions from

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Mag-Bind® Environmental DNA 96 Kit: High Quality Extractions from Inhibitor-rich Samples

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The characterization of the metagenomics of an ecosystem is an integral part of environmental research and understanding the role microorganisms play within their ecosystem. However, isolating high-quality DNA to allow for this characterization can be a challenge when it is being extracted from samples rich in inhibitors, such as humic and fulvic acid. The Mag-Bind®

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