Clean Up

Using ddPCR to Detect Rare Variant Alleles in cfDNA Samples on the MagBinder® Fit24 Platform

Application Notes, Clean Up, Downstream Applications, Oncology, Precision Medicine, Product Application / By

Carisa Townsend1, Kiranmai Durvasula1, Julie Baggs1, and Travis Butts1 Omega Bio-tek, Inc, Norcross, GA 30071 Introduction Recent advancements and studies have demonstrated the potential of cfDNA as a universal, non-invasive biomarker in cancer prognosis, diagnosis, and prenatal testing. cfDNA are found in low abundance and in a background of contaminating genomic DNA making it a […]

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RNA Depletion in Plasmid DNA Extractions with Mag-Bind® TotalPure NGS

Clean Up, Downstream Applications, Product Application / By

Introduction Traditionally, plasmid DNA purification hinges on alkaline lysis. In this method, bacteria, typically E. coli, containing the targeted plasmid DNA are harvested from overnight culture and resuspended in solution. A highly alkaline solution containing a detergent lyses the bacteria cells and denatures both the plasmid and genomic DNA. The addition of a highly acidic

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