Key Applications of Nucleic Acid Clean-up

Clean-up Kits remove inhibitors and other impurities from nucleic acid samples to improve the outcomes of downstream applications like NGS and PCR, among others.

  • NGS: Library preparation is the first step of Next-generation sequencing, and DNA cleanup is heavily involved in this step. Achieving inhibitor-free DNA is critical for NGS to reach its full potential
  • PCR: Some of the most common sample types, like blood, tissues, and soil, contain many inhibitors. Extracting nucleic acids free of those inhibitors ensures that amplification is successful.

Implications of Nucleic Acid Purification in Clean-up

  • Proper removal of inhibitors like excess nucleotides, primers, and pimer-dimers is imperative for successful library preparation for Next-Generation Sequencing.
  • Omega Bio-tek’s products, like Mag-Bind TotalPure NGS and Mag-Bind SeqDTR, are specially designed to eliminate inhibitors and other unwanted components, such as dye terminators, enabling optimized NGS library preparation.


Monteiro, D. A., do Rêgo Barros, P. S., Neto, M. D. S. R., da Cruz, H. L. A., Santos, L. R. C., de Arruda Santana, A. C., … & da Costa Rachid, C. T. C. (2022). Use of magnetic beads in Next-Generation Sequencing in the construction of low cost 16S rRNA gene genomic libraries. Pesquisa Agropecuária Pernambucana27(2).


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