Oncology
Key Applications of Nucleic Acid Purification in Oncology
Nucleic acid purification plays a crucial role in oncology by enabling the extraction and analysis of DNA and RNA from tumor samples. These extractions enable several downstream applications:
- Tumor profiling: cfDNA isolation gives way to analysis of specific genes, mutations, and alterations associated with cancer development and progression.
- Targeted therapy: matching therapies to the genomic profile of the tumor improves treatment response rates and minimizes unnecessary treatments.
Implications of Nucleic Acid Purification in Oncology
- Solid biopsies of tumors are typically stored in FFPE, which can limit the amount of sample available for testing.
- Liquid biopsies are typically used to sample cfDNA which occurs in small amounts near the tumor.
- These limitations in access to large amounts of samples can dampen the downstream potential of these extractions.
- Products like the Mag-Bind FFPE DNA/RNA Kit and Mag-Bind cfDNA Kit are able to extract high quality nucleic acids from these samples, even if they occur in small amounts.
Omega Bio-tek Products for Oncology Applications
Plasma/Serum (cfDNA):
Formalin Fixed Tissue (FFPE):
- Mag-Bind FFPE DNA/RNA 96 Kit
- Mag-Bind FFPE DNA Kit
- Mag-Bind FFPE RNA Kit
- E.Z.N.A. FFPE DNA Kit
- E.Z.N.A. FFPE RNA Kit
Blood and Tissue:
- Mag-Bind Blood & Tissue DNA HDQ 96 Kit
- Mag-Bind Blood & Tissue DNA HDQ 96 Prefilled Kit
- MB Fit24™ Blood & Tissue DNA Kit
Tissue and Cells:
Resources:
Zviran, A., Schulman, R. C., Shah, M., Hill, S. T., Deochand, S., Khamnei, C. C., … & Landau, D. A. (2020). Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring. Nature medicine, 26(7), 1114-1124.
