Key Applications of Nucleic Acid Purification in Oncology

Nucleic acid purification plays a crucial role in oncology by enabling the extraction and analysis of DNA and RNA from tumor samples. These extractions enable several downstream applications:

  • Tumor profiling: cfDNA isolation gives way to analysis of specific genes, mutations, and alterations associated with cancer development and progression.
  • Targeted therapy: matching therapies to the genomic profile of the tumor improves treatment response rates and minimizes unnecessary treatments.

Implications of Nucleic Acid Purification in Oncology

  • Solid biopsies of tumors are typically stored in FFPE, which can limit the amount of sample available for testing.
  • Liquid biopsies are typically used to sample cfDNA which occurs in small amounts near the tumor.
  • These limitations in access to large amounts of samples can dampen the downstream potential of these extractions.
  • Products like the Mag-Bind FFPE DNA/RNA Kit and Mag-Bind cfDNA Kit are able to extract high quality nucleic acids from these samples, even if they occur in small amounts.


Zviran, A., Schulman, R. C., Shah, M., Hill, S. T., Deochand, S., Khamnei, C. C., … & Landau, D. A. (2020). Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring. Nature medicine26(7), 1114-1124.

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