Oncology

Using ddPCR to Detect Rare Variant Alleles in cfDNA Samples on the MagBinder® Fit24 Platform

Carisa Townsend1, Kiranmai Durvasula1, Julie Baggs1, and Travis Butts1 Omega Bio-tek, Inc, Norcross, GA 30071 Introduction Recent advancements and studies have demonstrated the potential of cfDNA as a universal, non-invasive biomarker in cancer prognosis, diagnosis, and prenatal testing. cfDNA are found in low abundance and in a background of contaminating genomic DNA making it a […]

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The Challenges of cfDNA Purification

Cell-free DNA (cfDNA) has emerged as a revolutionary tool in the realm of molecular diagnostics, offering a non-invasive window into the genetic information of various bodily tissues. As discussed in a previous post, the development of cfDNA technology is a large step forward in detecting and profiling circulating biomarkers to derive clinically relevant information. However,

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What is NGS?

Next-Generation Sequencing (NGS) is a cutting-edge technology used to sequence nucleotides in a DNA or RNA molecule. Unlike Sanger Sequencing, which can sequence only one DNA fragment at a time, NGS allows researchers to sequence multiple DNA fragments in parallel in a single run. This high-throughput approach revolutionizes our ability to decode complex genomes efficiently

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Liquid vs. Solid Biopsy

Revolutionary advancements in medical technologies have armed physicians with state-of-the-art methods for detecting and monitoring cancer.  Two of these methods are liquid and solid biopsies which provide physicians and researchers with integral information about a patient’s condition.  What is a Solid Biopsy? Solid biopsies are the traditional method of analyzing tumors; this typically involves extracting samples of tissue from the tumor using a needle or

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Mag-Bind® FFPE DNA Kit: The Ultimate Solution for Genomic DNA Purification from Formalin-Fixed Paraffin-Embedded Tissue Samples

Formalin-fixed paraffin-embedded (FFPE) tissue samples are commonly used for preserving and storing biological samples, such as cancer tumor samples, for future analysis. However, the formalin fixation and paraffin embedding process can significantly impact the quality and yield of extracted DNA, making it challenging for downstream applications such as PCR and NGS. Omega Bio-tek developed the Mag-Bind® FFPE

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Collaborators from Cornell Medical College, the Fred Hutchinson Cancer Research Center, and the New York Genome Center Achieves Superior circulating, cell-free DNA Extraction Using Omega Bio-tek’s Mag-Bind® cfDNA Kit

Research publication review and discussion: “Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring”, Nature Medicine. Circulating, cell-free DNA (cfDNA) holds great clinical significance for non-invasive disease detection, diagnosis, and monitoring for tumor, cancer, or fetal DNA studies. Circulating DNA extraction is often challenging as they are found in low quantities, and accurate, consistent methods

Collaborators from Cornell Medical College, the Fred Hutchinson Cancer Research Center, and the New York Genome Center Achieves Superior circulating, cell-free DNA Extraction Using Omega Bio-tek’s Mag-Bind® cfDNA Kit Read More »

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